Selected Publications
Selected Publications
Selected Publications
2022
USP1-trapping lesions as a source of DNA replication stress and genomic instability
Coleman KE, Yin Y, Kit Leng Lui S, Keegan S, Fenyo D, Smith DJ, Rothenberg E, Huang TT
Nature Communications (2022)
Single-cell transcriptomics identifies Gadd45b as a regulator of herpesvirus-reactivating neurons
Hu H-L, Srinivas KP, Shuoshuo W, Chao MV, Lionnet T, Mohr I, Wilson AC, Depledge DP, Huang TT
EMBO Reports (2022)
2021
A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease
Patchett S, Lv Z, Rut W, Bekes M, Drag M, Olsen SK, Huang TT
Cell Reports (2021)
Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling
Lee WTC, Yin Y, Morten MJ, Tonzi P, Gwo PP, Odermatt DC, Modesti M, Cantor SB, Gari K, Huang TT, Rothenberg E
Molecular Cell (2021)
A basal-level activity of ATR links replication fork surveillance and stress response
Yin Y, Lee WTC, Gupta D, Tonzi P, Borowiec JA, Huang TT, Modesti M, Rothenberg E
Molecular Cell (2021)
WEE1i-ATRi combination therapy: a promising low-dose treatment for CCNE1-amplified gynecologic cancers
Goehring L, Huang TT
Cell Reports Medicine Preview (2021)
Monitoring genome-wide replication fork directionality by Okazaki fragment sequencing in mammalian cells
Kit Leng Lui S, Keegan S, Tonzi P, Kahli M, Chen Y-H, Chalhoub N, Coleman KE, Fenyo D, Smith D, Huang TT
Nature Protocols (2021)
2020
Hyperactive CDK2 activity in basal-like breast cancer imposes a genome integrity liability that can be exploited by targeting DNA polymerase E
Sviderskiy V, Blumenberg L, Gorodetsky E, Karakousi TR, Hirsh N, Alvarez SW, Terzi EM, Kaparos E, Whiten GC, Ssebyala S, Tonzi P, Mir H, Neel BG, Huang TT, Adams S, Ruggles KV, Possemato R
Molecular Cell (2020)
Roles for MDC1 in cancer development and treatment
Ruff S, Logan SK, Garabedian MJ, Huang TT
DNA Repair (2020)
Transcription-replication conflicts as a source of common fragile site instability caused by BMI1-RNF2 deficiency
Sanchez A, de Vivo A, Tonzi P, Kim J, Huang TT, Kee Y
PLoS Genetics (2020)
Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design
Rut W, Lv Z, Zmudzinski M, Patchett S, Nayak D, Snipas S, El Oualid F, Huang TT, Bekes M, Drag M, Olsen SK
Science Advances (2020)
Using Primary SCG Neuron Cultures to Study Molecular Determinants of HSV-1 Latency and Reactivation
Hu H-L, Srinivas KP, Mohr I, Huang TT, Wilson AC
Herpes Simplex Virus (2020)
2019
Role of Y-family translesion DNA polymerases in replication stress: Implications for new cancer therapeutic targets
Tonzi P, Huang TT
DNA Repair (2019)
TOP2b-dependent nuclear DNA damage shapes extracellular growth factor responses via dynamic AKT phosphorylation to control virus latency
Hu H-L, Shiflett LA, Kobayashi M, Chao MV, Wilson AC, Mohr I, Huang TT
Molecular Cell (2019)
Transcription shapes DNA replication initiation and termination in human cells​
Chen YH, Keegan S, Kahli M, Tonzi P, Fenyo D, Huang TT, Smith, DJ
Nature Structural & Molecular Biology (2019)
2018
Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery
Tonzi P, Yin Y, Lee CWT, Rothenberg E, Huang, TT
Elife (2018)
In a Class of Its Own: A New Family of Deubiquitinases Promotes Genome Stability
Coleman KE; Huang TT
Molecular Cell (2018)
The COP9 signalosome inhibits Cullin-RING E3 ubiquitin ligases independently of its deneddylase activity
Suisse A, Bekes M, Huang TT; Treisman JE
Fly (2018)
2017
SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function
Coleman KE, Bekes M, Chapman JR, Crist SB, Jones MJK, Ueberheide BM, Huang TT
ELife (2017)
2016
Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease
Bekes M, van der Heden vN, Gerbrand J, Ekkebus R, Ovaa H, Huang TT, Lima CD
Molecular Cell (2016)
How SUMOylation Fine-Tunes the Fanconi Anemia DNA Repair Pathway
Coleman KE, Huang TT
Frontiers In Genetics (2016)
Role of Deubiquitinating Enzymes in DNA Repair
Kee Y, Huang TT
Molecular & Cellular Biology (2016)
2015
ATR-mediated phosphorylation of FANCI regulates dormant origin firing in response to replication stress
Chen YH, Jones MJK, Yin Y, Crist SB, Colnaghi L, Sims RJ, Rothenberg E, Jallepalli PV, Huang TT
Molecular Cell (2015)
SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme
Bekes M, Rut W, Kasperkiewicz P, Mulder MP, Ovaa H, Drag M, Lima CD, Huang TT
Biochem J. (2015)
2014
Co-opting the Fanconi Anemia Genomic Stability Pathway Enables Herpesvirus DNA Synthesis and Productive Growth
Karttunen H, Savas JN, McKinney C, Chen YH, Yates JR, Hukkanen V, Huang TT, Mohr I
Molecular Cell (2014)
2013
DUB-Resistant Ubiquitin to Survey Ubiquitination Switches in Mammalian Cells
Bekes M, Okamoto K, Crist SB, Jones MJ, Chapman JR, Brasher BB, Melandri FD, Ueberheide BM, Lazzerini Denchi E, Huang TT
Cell Reports (2013)
2012
Deubiquitinases as a Signaling Target of Oxidative Stress
Cotto-Rios XM, Bekes M, Chapman J, Ueberheide B, Huang TT
Cell Reports (2012)
The Auto-Generated Fragment of the Usp1 Deubiquitylase Is a Physiological Substrate of the N-End Rule Pathway
Piatkov KI, Colnaghi L, Bekes M, Varshavsky A, Huang TT
Molecular Cell (2012)
The Fanconi anemia pathway in replication stress and DNA crosslink repair
Jones MJK, Huang TT
Cellular & Molecular Life Sciences: CMLS (2012)
Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability
Jones MJ, Colnaghi L, Huang TT
EMBO J. (2012)
2011
Insights into phosphorylation-dependent mechanisms regulating USP1 protein stability during the cell cycle
Cotto Rios XM, Jones MJ, Huang TT
Cell Cycle (2011)
APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage
Cotto-Rios XM; Jones MJK, Busino L, Pagano M, Huang TT
Journal of Cell Biology (2011)
Patient-derived C-terminal mutation of FANCI causes protein mislocalization and reveals putative EDGE motif function in DNA repair
Colnaghi L, Jones MJK, Cotto-Rios XM, Schindler D, Hanenberg H, Huang TT
Blood (2011)
2007
FANCI is a second monoubiquitinated member of the Fanconi anemia pathway
Sims, AE, Spiteri E, Sims RJ, Arita AG, Lach FP, Landers T, Wurm M, Freund M, Neveling K, Hanenberg H, Auerbach AD, Huang, Tony T
Nature Structural & Molecular Biology (2007)